Top Endocrine Publications of 2013: Canine & Feline Parathyroid & Calcium Disorders

In my third compilation of the canine and feline endocrine publications of 2013, I’m moving on to disorders of the parathyroid gland, including the clinical problems of hypercalcemia and hypocalcemia.

Listed below are 21 research papers written in 2013 that deal with a variety of topics and issues related to calcium, parathyroid or vitamin D metabolism.

These range from the interactions of calcitriol, calcidiol, parathyroid hormone, and fibroblast growth factor-23 in the pathogenesis of chronic kidney disease (1) to a number of reports of dogs with hypercalcemia of malignancy (2,4,5,7,16); from a review of hypocalcemia associated with critical illness (3) to a case of reversible myocardial failure associated with primary hypoparathyroidism in a cat (6); from a study of preoperative factors that help predict iatrogenic hypoparathyroidism following parathyroid surgery (8) to reviews of the emergency management of common metabolic abnormalities, including hypocalcemia, in cats that present with collapse (9,10); and from a study of the forms of dietary potassium in the prevention of calcium oxalate urolith formation in cats (11) to the effect of bone meal on urinary calcium and oxalate excretion in cats (12).

Other papers include a review of cholecalciferol (vitamin D3) intoxication leading to hypercalcemia (13) to changes in serum concentrations of calcium, phosphorus, magnesium, parathyroid hormone, calcidiol and calcitriol in growing cats (14) to a study of the plasma calcitonin response associated with hypocalcemia in cats (15); from a study of the vitamin D status in dogs with non-neoplastic and neoplastic esophageal nodules resulting from the nematode spirocercosis (17) to a case report of hypercalcemia secondary to Addison's disease in a cat (18); and finally, from a report of 3 cats with severe hypercalcemia secondary to vitamin D intoxication caused by ingestion of commercial cat foods (19) to a case report of a Persian cat that developed hypercalcemia secondary to intra-abdominal fungal pseudomycetoma (i.e., dermatophyte penetration into the abdominal cavity) (21) .

References:

1. de Brito Galvao JF, Nagode LA, Schenck PA, et al. Calcitriol, calcidiol, parathyroid hormone, and fibroblast growth factor-23 interactions in chronic kidney disease. J Vet Emerg Crit Care (San Antonio) 2013;23:134-162. 
2. Geigy C, Riond B, Bley CR, et al. Multiple myeloma in a dog with multiple concurrent infectious diseases and persistent polyclonal gammopathy. Vet Clin Pathol 2013;42:47-54. 
3. Holowaychuk MK. Hypocalcemia of critical illness in dogs and cats. Vet Clin North Am Small Anim Pract 2013;43:1299-1317, vi-vii. 
4. Javanbakht J, Tavassoli A, Sabbagh A, et al. Evaluation of an anal sac adenocarcinoma tumor in a Spitz dog. Asian Pac J Trop Biomed 2013;3:74-78. 
5. Javanbakht J, Tavassoli A, Sasani F, et al. An overall assessment of circumanal gland adenoma in a terrier mix breed dog. Asian Pac J Trop Biomed 2013;3:580-583. 
6. Lie AR, Macdonald KA. Reversible myocardial failure in a cat with primary hypoparathyroidism. J Feline Med Surg 2013;15:932-940. 
7. Merrick CH, Schleis SE, Smith AN, et al. Hypercalcemia of malignancy associated with renal cell carcinoma in a dog. J Am Anim Hosp Assoc 2013;49:385-388. 
8. Milovancev M, Schmiedt CW. Preoperative factors associated with postoperative hypocalcemia in dogs with primary hyperparathyroidism that underwent parathyroidectomy: 62 cases (2004-2009). J Am Vet Med Assoc 2013;242:507-515. 
9. Murphy K, Hibbert A. The flat cat: 1. a logical and practical approach to management of this challenging presentation. J Feline Med Surg 2013;15:175-188. 
10. Murphy K, Hibbert A. The flat cat: 2. the emergency database and management of common metabolic abnormalities. J Feline Med Surg 2013;15:189-199. 
11. Passlack N, Brenten T, Neumann K, et al. Effects of potassium chloride and potassium bicarbonate in the diet on urinary pH and mineral excretion of adult cats. Br J Nutr 2013:1-13. 
12. Passlack N, Zentek J. Urinary calcium and oxalate excretion in healthy adult cats are not affected by increasing dietary levels of bone meal in a canned diet. PLoS One 2013;8:e70530. 
13. Peterson ME, Fluegeman K. Cholecalciferol. Topics in companion animal medicine 2013;28:24-27. 
14. Pineda C, Aguilera-Tejero E, Guerrero F, et al. Mineral metabolism in growing cats: changes in the values of blood parameters with age. J Feline Med Surg 2013;15:866-871. 
15. Pineda C, Aguilera-Tejero E, Raya AI, et al. Assessment of calcitonin response to experimentally induced hypercalcemia in cats. Am J Vet Res 2013;74:1514-1521. 
16. Robat CS, Cesario L, Gaeta R, et al. Clinical features, treatment options, and outcome in dogs with thymoma: 116 cases (1999-2010). J Am Vet Med Assoc 2013;243:1448-1454. 
17. Rosa CT, Schoeman JP, Berry JL, et al. Hypovitaminosis D in dogs with spirocercosis. J Vet Intern Med 2013;27:1159-1164. 
18. Sicken J, Neiger R. Addisonian crisis and severe acidosis in a cat: a case of feline hypoadrenocorticism. J Feline Med Surg 2013;15:941-944. 
19. Wehner A, Katzenberger J, Groth A, et al. Vitamin D intoxication caused by ingestion of commercial cat food in three kittens. J Feline Med Surg 2013;15:730-736. 
20. Williams TL, Elliott J, Berry J, et al. Investigation of the pathophysiological mechanism for altered calcium homeostasis in hyperthyroid cats. J Small Anim Pract 2013;54:367-373. 
21. Zafrany A, Ben-Oz J, Segev G, et al. Successful treatment of an intra-pelvic fungal pseudomycetoma causing constipation and hypercalcaemia in a Persian cat. J Feline Med Surg 2013.