Top Endocrine Publications of 2012: Canine and Feline Endocrine Nutrition

In my 11th and last compilation of canine and feline endocrine publications of 2012, I’m finishing up with endocrine nutrition and treatment of obesity in dogs and cats. Starting in February of 2014, I'm planning to start posting the endocrine publications for 2013. I'm only waiting for the final papers published in December to come out so they can be included in my lists and reviews.

Listed below are 31 research papers written in 2012 that deal with a variety of topics concerning endocrine nutrition or obesity in the dog and cat. Remember that adipose tissue is the largest endocrine gland in the body, making a number of hormones, including leptin, adiponectin, and resistin. These hormones generally influence energy metabolism, which is of great interest to the understanding and treatment of type 2 diabetes and obesity.

These papers range from the studies of the effects of calcium deficiency in growing and adult dogs (1) to studies of the effect of dietary fat intake on circulating lipids in cats (2); from cause, prevalence, and management of obesity in dogs and cats (3,4,12-16,21,25-27,30) to the effect of nutrition on calcium oxalate and calcium excretion in cats (7,8); and from the effects on dietary L-carnitine supplementation on metabolism in cats (4) to the changes in fat-free mass and leptin in hyperthyroid cats before and after treatment (11,18).

Other research studies include the influence of dietary composition on the circulating glucose and insulin response to feeding (9,10) to factors that regulate serum leptin and adiponectin concentrations in dogs and cats (12,20,21,23) and studies of the role of dietary selenium and iodine on nutrition and metabolism (22,31). Finally, this lists also includes a excellent paper on dietary hyperthyroidism in dogs (19) — where we are reminded that not all dogs with thyrotoxicosis have a hyperfunctioning thyroid carcinoma!

2012 Papers on Endocrine Nutrition and Obesity:

1. Becker N, Kienzle E, Dobenecker B. Calcium deficiency: a problem in growing and adult dogs: two case reports. Tierarztl Prax Ausg K Kleintiere Heimtiere 2012;40:135-139. 
2. Butterwick RF, Salt C, Watson TD. Effects of increases in dietary fat intake on plasma lipid and lipoprotein cholesterol concentrations and associated enzyme activities in cats. Am J Vet Res 2012;73:62-67. 
3. Cave NJ, Allan FJ, Schokkenbroek SL, et al. A cross-sectional study to compare changes in the prevalence and risk factors for feline obesity between 1993 and 2007 in New Zealand. Prev Vet Med 2012;107:121-133. 
4. Center SA, Warner KL, Randolph JF, et al. Influence of dietary supplementation with l-carnitine on metabolic rate, fatty acid oxidation, body condition, and weight loss in overweight cats. Am J Vet Res 2012;73:1002-1015. 
5. Clark MH, Hoenig M, Ferguson DC, et al. Pharmacokinetics of pioglitazone in lean and obese cats. J Vet Pharmacol Ther 2012;35:428-436. 
6. Corbee RJ, Tryfonidou MA, Meij BP, et al. Vitamin D status before and after hypophysectomy in dogs with pituitary-dependent hypercortisolism. Domest Anim Endocrinol 2012;42:43-49. 
7. Dijcker JC, Hagen-Plantinga EA, Everts H, et al. Dietary and animal-related factors associated with the rate of urinary oxalate and calcium excretion in dogs and cats. Vet Rec 2012;171:46. 
8. Dijcker JC, Kummeling A, Hagen-Plantinga EA, et al. Urinary oxalate and calcium excretion by dogs and cats diagnosed with calcium oxalate urolithiasis. Vet Rec 2012;171:646. 
9. Elliott KF, Rand JS, Fleeman LM, et al. A diet lower in digestible carbohydrate results in lower postprandial glucose concentrations compared with a traditional canine diabetes diet and an adult maintenance diet in healthy dogs. Res Vet Sci 2012;93:288-295. 
10. Farrow H, Rand JS, Morton JM, et al. Postprandial glycemia in cats fed a moderate carbohydrate meal persists for a median of 12 hours -- female cats have higher peak glucose concentrations. J Feline Med Surg 2012;14:706-705. 
11. Finch NC, Welsh CP, Hibbert A. Changes in fat-free mass (FFM) in cats undergoing radioactive iodine therapy. J Feline Med Surg 2012;14:652-653.
12. German AJ. Barking up the wrong tree: what's the deal with obesity, adiponectin and inflammation in dogs? Vet J 2012;194:272-273.
13. German AJ, Holden SL, Morris PJ, et al. Long-term follow-up after weight management in obese dogs: the role of diet in preventing regain. Vet J 2012;192:65-70. 
14. German AJ, Holden SL, Wiseman-Orr ML, et al. Quality of life is reduced in obese dogs but improves after successful weight loss. Vet J 2012;192:428-434. 
15. Haring T, Haase B, Zini E, et al. Overweight and impaired insulin sensitivity present in growing cats. J Anim Physiol Anim Nutr (Berl) 2012; doi: 10.1111/j.1439-0396.2012.01322.x. 
16. Hoenig M. The cat as a model for human obesity and diabetes. J Diabetes Sci Technol 2012;6:525-533. 
17. Hutchinson D, Freeman LM, McCarthy R, et al. Seizures and severe nutrient deficiencies in a puppy fed a homemade diet. J Am Vet Med Assoc 2012;241:477-483. 
18. Jaillardon L, Burger M, Siliart B. Leptin levels in hyperthyroid cats before and after treatment. Vet Rec 2012;170:155. 
19. Köhler B, Stengel D, Neiger R. Dietary hyperthyroidism in dogs. J Small Anim Pract 2012;53:182-184. 
20. Mazaki-Tovi M, Abood SK, Schenck PA. Effect of omega-3 polyunsaturated fatty acids and body condition on serum concentrations of adipokines in healthy dogs. Am J Vet Res 2012;73:1273-1281. 
21. Ricci R, Bevilacqua F. The potential role of leptin and adiponectin in obesity: a comparative review. Vet J 2012;191:292-298. 
22. Todd SE, Thomas DG, Bosch G, et al. Selenium status in adult cats and dogs fed high levels of dietary inorganic and organic selenium. J Anim Sci 2012;90:2549-2555. 
23. Tvarijonaviciute A, Ceron JJ, Martinez-Subiela S, et al. Serum and urinary adiponectin in dogs with renal disease from leishmaniasis. Vet Rec 2012;171:297. 
24. Tvarijonaviciute A, German AJ, Martinez-Subiela S, et al. Analytical performance of commercially-available assays for feline insulin-like growth factor 1 (IGF-1), adiponectin and ghrelin measurements. J Feline Med Surg 2012;14:138-146. 
25. Tvarijonaviciute A, Ceron JJ, Holden SL, et al. Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome. BMC Vet Res 2012;8:147. h
26. Tvarijonaviciute A, Tecles F, Martinez-Subiela S, et al. Effect of weight loss on inflammatory biomarkers in obese dogs. Vet J 2012;193570-572. 
27. Tvarijonaviciute A, Ceron JJ, Holden SL, et al. Effects of weight loss in obese cats on biochemical analytes related to inflammation and glucose homeostasis. Domest Anim Endocrinol 2012;42:129-141. 
28. Verbrugghe A, Hesta M, Daminet S, et al. Nutritional modulation of insulin resistance in the true carnivorous cat: a review. Crit Rev Food Sci Nutr 2012;52:172-182. 
29. Verkest KR, Fleeman LM, Morton JM, et al. Association of postprandial serum triglyceride concentration and serum canine pancreatic lipase immunoreactivity in overweight and obese dogs. J Vet Intern Med 2012;26:46-53. 
30. Verkest KR, Rand JS, Fleeman LM, et al. Spontaneously obese dogs exhibit greater postprandial glucose, triglyceride, and insulin concentrations than lean dogs. Domest Anim Endocrinol 2012;42:103-112.
31. Zicker S, B. S. Focus on nutrition: the role of iodine in nutrition and metabolism. Compendium 2012;34:E1-E4.