I'm writing to inquire if there is a consensus among the endocrine experts on the dose and frequency of administration of oral prednisone for an Addisonian dog on monthly Percorten injections.
i usually use about 0.1mg/kg SID, but some of my colleagues use 0.2mg/kg SID, whereas others using every other day (EOD) dosing at 0.1 - 0.2mg/kg each dose EOD).
i know each dog is different, and they may require more or less depending on "stressful" situations, but wanted to see if SID or EOD is the preferred frequency. I'd also like to know what dosage you recommend.
For dogs with spontaneous hypoadrenocorticism (Addison's disease), it makes the most sense to me to give the glucocorticoid supplementation on a daily basis.
There is no reason to give alternative day steroids to avoid adrenal suppression in these dogs, because the adrenals are already permanently atrophied or destroyed in dogs with Addison's disease. If you give alternate day prednisone, they would have no glucocorticoid reserve on the off day.
I dose prednisone or prednisolone at 0.1-0.2 mg/kg/day. If the dog develops polyuria and polydipsia (PU/PD) or any other signs of iatrogenic Cushing's syndrome, I would lower the dose as needed. I rarely, if ever, give a higher dose than 5-mg per day to ANY dog. The 5-mg dose is the average human maintenance dose, and we see very few dogs that weigh over 70 kg.