Top Endocrine Publications of 2010: The Canine and Feline Obesity

In my 10th and last compilation of the canine and feline endocrine publications of 2010, I’m finishing up with obesity disorders of dogs and cats. Surprised? Well, it turns out that adipose tissue is the largest endocrine gland in the body, making a number of hormones, including leptin, adiponectin, and resistin. These hormones generally influence energy metabolism, which is of great interest to the understanding and treatment of type 2 diabetes and obesity.

Listed below are 36 research papers written in 2010 that deal with a variety of topics of issues of clinical importance concerning obesity in the dog and cat.

These range from the studies of the cause, prevalence, and management of obesity (1-3,6,16,17,24,27,36) to the relationship been weight and survival (5) and lameness (18); from studies of noninvasive methods for estimating the percent body fat in dogs and cats (7,15) to the role inflammatory adipokines play in obese animals (8,13,28); and from studies of hypertriglyceridemia and hyperlipidemia in dogs and cats (10,12,14,34) to studies of the endocrinology of animal obesity (8,13,17).

References:

1. Bland IM, Guthrie-Jones A, Taylor RD, et al. Dog obesity: veterinary practices' and owners' opinions on cause and management. Preventive Veterinary Medicine 2010;94:310-315.
2. Courcier EA, O'Higgins R, Mellor DJ, et al. Prevalence and risk factors for feline obesity in a first opinion practice in Glasgow, Scotland. Journal of Feline Medicine and Surgery 2010;12:746-753.
3. Courcier EA, Thomson RM, Mellor DJ, et al. An epidemiological study of environmental factors associated with canine obesity. The Journal of Small Animal Practice 2010;51:362-367.
4. Fernandez-Real JM, Ortega F, Gomez-Ambrosi J, et al. Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss. Osteoporosis International 2010;21:2101-2107.
5. Finn E, Freeman LM, Rush JE, et al. The relationship between body weight, body condition, and survival in cats with heart failure. Journal of Veterinary Internal Medicine 2010;24:1369-1374.
6. German AJ, Holden SL, Bissot T, et al. A high protein high fibre diet improves weight loss in obese dogs. Veterinary Journal 2010;183:294-297.
7. German AJ, Holden SL, Morris PJ, et al. Comparison of a bioimpedance monitor with dual-energy x-ray absorptiometry for noninvasive estimation of percentage body fat in dogs. American Journal of Veterinary Research 2010;71:393-398.
8. German AJ, Ryan VH, German AC, et al. Obesity, its associated disorders and the role of inflammatory adipokines in companion animals. Veterinary Journal 2010;185:4-9.
9. Gilor C, Graves TK, Lascelles BD, et al. The effects of body weight, body condition score, sex, and age on serum fructosamine concentrations in clinically healthy cats. Veterinary Clinical Pathology 2010;39:322-328.
10. Hatano Y, Mori N, Asada M, et al. Hypertriglyceridemia with increased plasma insulin concentrations in cats. Research in Veterinary Science 2010;88:458-460.
11. Hoenig M, Jordan ET, Ferguson DC, et al. Oral glucose leads to a differential response in glucose, insulin, and GLP-1 in lean versus obese cats. Domestic Animal Endocrinology 2010;38:95-102.
12. Jeusette I, Torre C, Salas A, et al. Effects of consuming diets containing various fats or citrus flavanones on plasma lipid and urinary F2-isoprostane concentrations in overweight cats. American Journal of Veterinary Research 2010;71:1039-1044.
13. Kil DY, Swanson KS. Endocrinology of obesity. The Veterinary Clinics of North America: Small Animal Practice 2010;40:205-219.
14. Kluger EK, Caslake M, Baral RM, et al. Preliminary post-prandial studies of Burmese cats with elevated triglyceride concentrations and/or presumed lipid aqueous. Journal of Feline Medicine and Surgery 2010;12:621-630.
15. Lee H, Kim M, Choi M, et al. Assessment of feline abdominal adipose tissue using computed tomography. Journal of Feline Medicine and Surgery 2010;12:936-941.
16. Linder DE, Freeman LM. Evaluation of calorie density and feeding directions for commercially available diets designed for weight loss in dogs and cats. Journal of the American Veterinary Medical Association 2010;236:74-77.
17. Lubbs DC, Vester Boler BM, Ridge TK, et al. Dietary macronutrients and feeding frequency affect fasting and postprandial concentrations of hormones involved in appetite regulation in adult dogs. Journal of Animal Science 2010;88:3945-3953.
18. Marshall WG, Hazewinkel HA, Mullen D, et al. The effect of weight loss on lameness in obese dogs with osteoarthritis. Veterinary Research Communications 2010;34:241-253.
19. Martin LJ, Siliart B, Lutz TA, et al. Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats. The British Journal of Nutrition 2010;103:1610-1619.
20. Mitsuhashi Y, Nagaoka D, Ishioka K, et al. Postprandial lipid-related metabolites are altered in dogs fed dietary diacylglycerol and low glycemic index starch during weight loss. The Journal of Nutrition 2010;140:1815-1823.
21. Muranaka S, Mori N, Hatano Y, et al. Obesity induced changes to plasma adiponectin concentration and cholesterol lipoprotein composition profile in cats. Research in Veterinary Science 2010.
22. Newhall K, Nunamaker E, Gissendanner S, et al. CB-1 antagonism with LY2190416 results in acute weight loss in obese adult dogs fed a high-fat diet. Journal of Veterinary Pharmacology and Therapeutics 2010;33:615-618.
23. Nieminen P, Rouvinen-Watt K, Kapiainen S, et al. Molecular evolution of adiponectin in Carnivora and its mRNA expression in relation to hepatic lipidosis. General and Comparative Endocrinology 2010;168:307-311.
24. Nijland ML, Stam F, Seidell JC. Overweight in dogs, but not in cats, is related to overweight in their owners. Public Health Nutrition 2010;13:102-106.
25. Nishii N, Yamasaki M, Takasu M, et al. Plasma leptin concentration in dogs with diabetes mellitus. The Journal of Veterinary Medical Science 2010;72:809-811.
26. Piccione G, Giudice E, Fazio F, et al. Association between obesity and reduced body temperature in dogs. International Journal of Obesity 2010.
27. Rohlf VI, Toukhsati S, Coleman GJ, et al. Dog obesity: can dog caregivers' (owners') feeding and exercise intentions and behaviors be predicted from attitudes? Journal of Applied Animal Welfare Science 2010;13:213-236.
28. Ryan VH, German AJ, Wood IS, et al. Adipokine expression and secretion by canine adipocytes: Stimulation of inflammatory adipokine production by LPS and TNF alpha. Pflugers Archivive 2010;460:603-616.
29. Sieber-Ruckstuhl NS, Zini E, Osto M, et al. Effect of hyperlipidemia on 11beta-hydroxysteroid-dehydrogenase, glucocorticoid receptor, and leptin expression in insulin-sensitive tissues of cats. Domestic Animal Endocrinology 2010;39:222-230.
30. Slavov E, Georgiev IP, Dzhelebov P, et al. High-fat feeding and Staphylococcus intermedius infection impair beta cell function and insulin sensitivity in mongrel dogs. Veterinary Research Communications 2010;34:205-215.
31. Tvarijonaviciute A, Martinez-Subiela S, Ceron JJ. Validation of 2 commercially available enzyme-linked immunosorbent assays for adiponectin determination in canine serum samples. Canadian Journal of Veterinary Research 2010;74:279-285.
32. Tvarijonaviciute A, Tecles F, Ceron JJ. Relationship between serum butyrylcholinesterase and obesity in dogs: a preliminary report. Veterinary Journal 2010;186:197-200.
33. Verbrugghe A, Hesta M, Van Weyenberg S, et al. The glucose and insulin response to isoenergetic reduction of dietary energy sources in a true carnivore: the domestic cat ( Felis catus). The British Journal of Nutrition 2010;104:214-221.
34. Xenoulis PG, Steiner JM. Lipid metabolism and hyperlipidemia in dogs. Veterinary journal 2010;183:12-21.
35. Zini E, Osto M, Konrad D, et al. 10-day hyperlipidemic clamp in cats: effects on insulin sensitivity, inflammation, and glucose metabolism-related genes. Hormone and Metabolic Research 2010;42:340-347.
36. Zoran DL. Obesity in dogs and cats: A metabolic and endocrine disorder. The Veterinary Clinics of North America: Small Animal Practice 2010;40:221-239.